Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Abstract
A HPLC method for the detection and quantification of glibenclamide, from dissolution studies of glibenclamide tablets (5 mg), was developed. The dissolution test employed was the basket method, operating at 100 rpm, using 1000ml phosphate buffer pH 7.4 as the dissolution medium. Elution was performed on LC-18 reverse phase, SupelcosilTM ODS column (4.6mm x 25cm, 5mm) using a mobile phase consisting of 0.02M monobasic ammonium phosphate in 60%v/v acetonitrile in water at a flow rate of 2ml/min, using phenacetin as the internal standard. The eluent was monitored at 254nm with an UV detector. Retention times of the glibenclamide and phenacetin peaks were 3.61 minutes and 1.8 minutes respectively.
Abstract
A cross-sectional study was conducted among pharmacy students to determine factors influencing their choice of work place and to evaluate whether a one-year hospital pre-registration training programme had any effect on these choices. Questionnaires were distributed to graduating students at the School of Pharmaceutical Sciences, Universiti Sains Malaysia. The questionnaires were again sent to the same group of students by post at the end of their pre-registration training year. The response rate during the follow-up stage was 46%. Results indicated that students in the survey were more interested in independent and chain community pharmacies compared to other practice settings. Students’ choices of first place of practice appeared to be influenced by both intrinsic and extrinsic job factors. Our findings did not show major changes in students’ preferences for practice sites before and after the hospital pre-registration period. This information is expected to be useful for pharmacy employers.